Biomedical Bonding - A paradigm shift in bone restoration surgeries
project team
Professor Michael Malkoch
Project director
Michael Malkoch is professor in Functional Organic Nanomaterials. In 2003, he obtained his PhD in dendrimer chemistry from the department of Polymer Technology at KTH Royal Institute of Technology, Sweden. Shortly after, he joined Professor Craig J. Hawker, between 2003-2005, as a postdoctoral fellow at Stanford University, IBM Almaden Research Center and the Materials Research Laboratory in Santa Barbara (UCSB).
He has been awarded two distinguished fellowships from Swedish Research Council: Assistant Professor (VR-FOASS) in materials science and VR-senior research position (VR-Rådsforskare) in the field biomedical engineering. He is also selected as KAW Academy Fellow (2013 and 2018) in Engineering Science.
The Malkoch research group focuses on five main areas:
1) identifying novel and sustainable concepts to highly complex and functional macromolecules,
2) construction of precision dendritic drug delivery systems with emphasis on cancer.
3) fabrication of programmable networks with antibacterial properties to overcome current antibiotic resistance.
4) development of next generation biomaterials and methodologies for fixation and regeneration of damaged tissue and bones
5) polymer-based manipulations of generic surfaces towards sensitive biosensor applications.
His research portfolio is based on 25 years of collected experience from several universities and is reflected by over 100 internationally peer-reviewed publications excluding conference contributions. The interdisciplinary nature of the group research has allowed for publishing in high impact journals such as Advanced Materials, Advanced Functional Materials, Angewandte Chemie, JACS etc.
Dr. Peter Varga
Dr Peter Varga is the leader of the Biomechanics and Modelling focus area of the Biomedical Development Program at ARI and faculty Member of the Biomedical Engineering Master Program of the University of Bern.
Dr Varga obtained his PhD in bone biomechanics from the Technical University of Vienna. This work has been recognised with the "Award of Excellence 2010" of the Austrian Federal Minister for Science and Research. Prior to his position at ARI, Dr Varga had a postdoctoral fellowship at the Technical University of Vienna and a PI position at the Julius Wolff Institute at the Charité UM Berlin.
His research is focused on the biomechanical behaviour and failure of bone and bone-implant constructs and the computer simulation thereof. He currently serves as an academic editor for BioMed Research International.
Dr Varga has >62 peer-reviewed publications (H-index: 24), a book chapter and one patent. His current research interests are primarily focused on the biomechanical behaviour and failure of bone and bone-implant constructs and the computer simulation thereof.
This expertise will be employed to test the mechanical stability of the novel fracture fixation approach developed within the BoneFix project.
Website of the research group:
Profile page:
Professor Camilla Svensson
Professor Camilla Svensson is since 2008 a principal investigator and group leader at the Department of Physiology and Pharmacology and Center for Molecular Medicine at Karolinska Institutet in Sweden. She has extensive experience from research in the pain/rheumatology interface and her research focuses on molecular and cellular mechanisms underlying persistent pain in conditions with autoimmune and bone-related pathologies. Professor Svensson’s laboratory combines neuroscience, pharmacology, and immunology with an emphasis on translational research and the team is engaged in several collaborations with clinical researcher and engineering groups, with the goal to bring basic research findings from the lab bench to clinical and commercial applications. Professor Svensson’s research is funded by both the Swedish and European Research councils, the Knut and Allice Wallenberg Foundation, the family Lundblad Foundation and the Swedish Foundation for Strategic Research.
Professor Svensson served as a member and the president of the Young Academy of Sweden. Currently she serves on the executive board of the Department of Physiology and Pharmacology at the Karolinska Institutet, she is member of the board for the Scandinavian Association for the Study of Pain, an associate editor for the Scandinavian Journal of Pain and she serves on scientific advisory boards for several companies. She received her PhD in Molecular Pathology from University of California, San Diego in the US in 2005, where she also undertook three years postdoctoral training in rheumatology. Since she established her laboratory at the Karolinska Institutet in Stockholm she has received several prestigious awards and grants, including the Early Career Award from the International Association for the Study of Pain and the Future Research Leader grant from Swedish Foundation for Strategic Research. She is a Ragnar Söderberg Fellow in Medicine and a Wallenberg Academy Scholar.​
Karolinska Institutet/Professor/Camilla Svensson/Molecular Pain group/https://www.cmm.ki.se/camilla-svensson-grupp
Mattias Ohrlander
Mattias Ohrlander is the COO of Biomedical Bonding. With a masters and PhD in Polymer Chemistry from KTH Royal Institute of Technology, he has over 25 years of experience in the MedTech industry. Mattias' broad range of experiences includes R&D, regulatory and IP affairs, business development, clinical studies and commercialisation in the field of medical devices. Over the years, he has built an extended network with several research groups within biomaterial-, biointerphase-, and surface-science, as well as with key opinion leaders for the use of various medical devices. Furthermore, he has established a long track record in joint collaboration projects with successful commercialisation of several new products as a result.
Dr. Daniel Hutchinson
Project coordinator
Dr Daniel Hutchinson is acting as project coordinator and manager for the BoneFix project. He is also a senior researcher in the Malkoch group in the Department of Fibre and Polymer Technology, KTH Royal Institute of Technology in Stockholm, Sweden.
Dr Hutchinson has worked as a postdoc in the Malkoch group since 2018, focusing on the development of light-curable adhesives for use in bone fracture fixation. He has been involved in all aspects of the adhesive development, from monomer synthesis, to testing the adhesive’s mechanical properties, to the ex vivo and in vivo evaluation of the fixation properties of the adhesive on bone fractures. In the BoneFix project he will be supervising the synthesis of monomers and polymers for use in the bone substitution and adhesive fixation patch domains of the bone restoration patch.
Before joining the Malkoch group, Dr Hutchinson primarily worked on synthesising responsive, metal-coordinating molecular strands and studying the conformation of their metal complexes. In 2013, he graduated with a PhD from the University of Otago, New Zealand, where he created polymer gels whose swelling was controlled by the metal-induced conformational changes of the molecular strands built into the gel network. Before moving to Sweden, he worked as a postdoctoral fellow of the Alexander von Humboldt foundation at the University of Leipzig, Germany, where he focused on the synthesis of versatile heterobimetallic complexes for catalysis
Professor David Eglin
David Eglin is Professor of Biomaterials Science and Engeneering at the Center for Biomedical and Healthcare Engineering, at Mines Saint Etienne, France since 2020. He holds the chair of Translational Biomaterials Research in Orthopedics at the University of Twente, The Netherlands, since June 2019.
He has extensive expertise in the synthesis and processing of responsive materials based on biopolymers such as hyaluronic acid and collagen. He designs, syntheses, and characterizes biopolymers derivatives and composites with endowed stimuli responsive behavior. He develops processes for the delivery of biologics and drugs, and for the creation of microenvironments to control cell behavior. His group is notably developing additive manufacturing and biofabrication processes for both basic understanding of biomaterials and cells interaction, and for translational research in the orthopedic field.
In 2011, Prof Eglin was given the Jean Leray award by the European Society for Biomaterials for outstanding research contributions to the field of biomaterials. He has published over 150 peer-reviewed articles and book chapters, as well as eight patents. He has just completed his term as president of the Swiss Society of Biomaterials and Regenerative Medicine and is the current treasurer of the European Chapter of the Tissue Engineering and Regenerative Medicine International Society.
Center for Biomedical and Healthcare Engineering (CIS)
Webpage:
Dr. Christian Wong
Biosketch - Christian Wong Christian Wong is a full-time consultant at the children's section, Hvidovre Hospital, Copenhagen. He became a medical doctor in 1995, received a PhD study degree in 2001, and became an orthopedic surgery specialist in 2006.
After working with general fracture and prosthesis surgery, he joined the pediatric orthopedic section at Hvidovre hospital in 2010. Here, he worked in a highly specialized function with children with cerebral palsy (CP). He became a consultant in 2013 with special interest in surgical treatment of children with CP. In the course of the last 3-4 years, he discovered an overlooked important and insufficiently treated problem for these children, namely pain, which is central for quality of life for these children.
This has not been addressed adequately either nationally or internationally. He has set up a small research group with special interest in aspects of pain and improved, novel surgery for these children. He is chairman and member in the Danish and European pediatric orthopedic research society, respectively. He is member of the specialist council innational patient organisation 'CP Danmark', and national and regional board for the national database for children with CP, CPOP.
He has supervised two PhD students, multiple for clinical interns, medical and engineering students in research projects. At conferences, he has had > 50 oral and poster presentations, and has held eight formally invited international and national lectures.
He is now supervising 3 PhD students and also has 1 full time researcher.
Total number of peer-reviewed publications 33. Number of first authorships 14. Number of corresponding authorships 14. Number of citations 698. H-index 10. Book chapters 3. He has received larger grants (>~500.000 dkk) from the Lundbeck foundation, the Jascha foundation, the ELSASS foundation, and the EC grants of Eurostars, Horizon 2020 - Marie Curie and Horizon 2020 -EIC-FETPROACT-2019.
Professor Kamal Mustafa
Professor Kamal Mustafa is the Head of the Tissue Engineering Group and the Leader of the Research Laboratory at the Department of Clinical Dentistry, Faculty of Medicine, University of Bergen in Norway since 2010. He has extensive management experience from life science and participation and coordination of European projects. Prof. Mustafa’s main research activities were incorporated in the large EU projects financed by the FP7 and H2020 and several projects financed by national funding agencies. He is currently leading and sponsoring a multicenter clinical trial to reconstruct alveolar bone using stem cells and biomaterials, which is among few trials in Europe using advanced cell therapy.His laboratory combines chemistry, biology, engineering with medicine to bring basic research findings from the lab bench to the clinic and commercial applications. He is one of the founders of Bergen Stem Cell Consortium and a committee member of the Research Council Board at the The Department of Clinical Dentistry. He received his PhD from Karolinska Institutet, Stockholm, Sweden in 2001. Prof. Mustafa was a post-doc at Karolinska Institute (Sweden) and associate professor at University of Bergen as well as visiting scientist in NIOM, Scandinavian Institute of Dental Materials, Oslo and University of North Carolina, Chapel Hill, USA and visiting professor in University of Malmo, Sweden. During the last 5 years, his research increasingly focused on the development of toolbox for bone regeneration according to the concept of tissue engineering. He is a frequently invited speaker at international events and has published >200 scientific papers.
